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KMID : 0385019920080020249
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Korean Journal of Laboratory Animal Science
1992 Volume.8 No. 2 p.249 ~ p.253
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The Study on Midium-term Carcinogenicity Bioassay of Porcine Somatotrophin
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Abstract
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This study was performed for assessing carcinogenecity of porcine somatotrophin(PST) using mid-term carcinogenecity bioassay.
Fischer 344 rats aged sip weeks divided into four groups and given an intraperitoneal injection of diethylnitrosamine at 200㎎/㎏ body weight. Two weeks after beginning of the experiment, group 1 was negative control treated with saline. Group 2 was begun to feed on water containing 0.05% phenobarbital sodium as a promotor for six weeks, arid PST was given intraperitoneally to rats of group 3(0.015㎎/150g B.W) and group 4(0.3㎎/150g B.W). Three weeks after beginning of the experiment, partial hepatectomy was performed in all rats. Preneoplastic foci were identified histopathologically by glutathione S-transferase placental form activity and quantitatively analyzed by immage analyzed. PST was not different as compared with negative control group. Therefore, it was concluded that PST didn´t have carcinogenic effect.
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